CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder primarily characterized by selective Camellia degeneration of both the upper motor neurons in the brain and lower motor neurons in the brain stem and the spinal cord.The exact mechanism for the selective death of neurons is unknown.A growing body of evide